个人简介

熊裕焱，男，西北大学生命科学与医学部教授、博士生导师，陕西省高层次人才专家。2014年博士毕业于瑞士University of Fribourg生理学专业。主要从事衰老、心血管疾病、2型糖尿病和肿瘤发病机制的研究。先后在心血管和细胞生物学领域权威期刊iScience、Autophagy、Diabetes、Cell death and disease和Aging cell等发表多篇论文，曾获得瑞士University of Fribourg最佳博士论文奖和欧洲动脉粥硬化协会(EAS)青年研究人员奖。

教育工作经历：

2019.10-至今 西北大学生命科学与医学部 教授 博导

2014.05-2019.09 University of Fribourg   Assistant-docteur

2011.04-2014.04  University of Fribourg（瑞士）  博士（生理学）

2007.09-2010.06  厦门大学  硕士（生物化工）

2003.09-2007.06  安徽科技学院  学士

主要研究方向：

（1）衰老和肥胖引起的心血管疾病和2型糖尿病发病机制的研究

（2）动脉粥样硬化临床诊断分子标志物的研究

（3）不同应激条件下mTOR信号通路调控分子机制的研究

（4）探究细胞凋亡和细胞自噬调节心血管疾病和肿瘤发病机制的研究

承担的科研项目

1. 西北大学科研启动经费，125万，主持

2. 陕西省科技厅自然科学基金项目，3万，主持

3. 陕西省留学人员科技活动择优资助项目，3万，主持

4. 陕西省高层次人才计划项目，80万，主持

5. 瑞士国家自然科学基金重大项目 Kidney Control of Homeostasis, WP II: Dietary impact - Dietary protein, acid and phosphate toxicity. NCCR-Kidney.ch 80万瑞士法郎， 参与

6. 瑞士国家自然科学基金Cell-Specific Pleiotropic Effects of Arginase-II on Obesity-Associated Metabolic and Vascular Disorders 2015-2018 Swiss Heart Foundation 47.4万瑞士法郎， 参与

7. 瑞士心脏协会基金 Macrophage-Specific Role of Arginase-II in Atherogenesis 7.2万 瑞士法郎，第二项目负责人

主要研究成果

1. Yi Yu, Diogo Ladeiras, Yuyan Xiong, Kayluz Frias Boligan, Xiujie Liang, Stephan von Gunten, Robert E. Hunger, Xiu‐Fen Ming,Zhihong Yang. Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. J Cell Physiol. 2020;1–15.

2. Yu Yi#, Xiong Yuyan#, Ladeiras Diogo, Yang Zhihong, Ming Xiu-Fen. Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. iScience, 2019, 19:39-53. (#共同第一作者)

3. Yi Yu#, Yuyan Xiong#, Jean-Pierre Montani, Zhihong Yang, and Xiu-Fen Ming. Myosin-1b mediates effects of arginase-II on mTORC1 activation through promoting lysosomal positioning and dissociation from TSC. Cell Death and Disease. 2018; 9:313 (#共同第一作者)

4. Yuyan Xiong, Gautham Yepuri, Sevil Necetin, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Ming. Arginase-II regulates mouse life span. Frontiers in Physiology. 2017; 8: 682.

5. Yuyan Xiong, Gautham Yepuri, Sevil Necetin, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Ming. Arginase-II promotes tumor necrosis factor-alpha release from pancreatic acinar cells causing beta-cell apoptosis in aging. Diabetes. 2017; 66:1636–1649

6. Huang J, Rajapakse A, Xiong Y, Montani J-P, Verrey F, Ming X-F, Yang Z. Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity. Frontiers in Physiology. 2016, 7:560. doi: 10.3389/fphys.2016.00560

7. Yu Y, Xiong Y, Montani JP, Yang Z, Ming XF.En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries. J Vis Exp. 2016 Feb 25;(108):53718.

8. Wu Z, Yu Y, Liu C, Xiong Y, Montani JP, Yang Z, Ming X-F. Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging-US. 2015;7(1):70-81.

9. Yuyan Xiong; Michael Forbiteh Fru; Yi Yu; Jean-Pierre Montani; Xiu-Fen Ming; Zhihong Yang. Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling. Aging-US. 2014, 6(5): 369-379.

10. Yuyan Xiong, Gautham Yepuri, Michael Forbiteh, Yi Yu, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Ming. Arginase-II impairs endothelial autophagy through regulation of mTOR and  AMPK signaling in advanced atherosclerosis. Autophagy. 2014, 10(12):2223-38.

11. Xiong Y, Yu Y, Montani JP, Yang Z, Ming XF. Arginase-II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its L-Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability. Journal of the American Heart Association. 2013 Jul 5; 2(4): e000096. doi: 10.1161/JAHA.113.000096.

12. Yepuri G#, Velagapudi S#, Xiong Y, Rajapakse AG, Montani JP, Ming XF, Yang Z. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell.2012, 11(6):1005-16.（#共同第一作者）

13. Ming X-F, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani J-P, Yang Z. Arginase-II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. Journal of the American Heart Association. 2012; 1: e000992doi:10.1161/JAHA.112.000992.

14. Carvas J M, Vukolic A, Yepuri G, Xiong Y, Popp K, Schmutz I, Chappuis S, Albrecht U, Ming X-F, Montani J-P and Yang Z. Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. Front. Physio. 2012:3:337. doi: 10.3389/fphys.2012.00337.

15. Wu Z, Xiong Y, Gajanayake T, Ming XF, Yang Z. p38 Mitogen-Activated Protein Kinase Is Required for Glucosamine-Induced Endothelial Nitric Oxide Synthase Uncoupling and Plasminogen-Activator Inhibitor Expression. Circ J. 2012; 76: 2015-2022.

16. Yuyan Xiong, Yuanpeng Wang, Yi Yu, Qingbiao Li, Haitao Wang, Ronghui Chen, Ning He. Production and characterization of a novel bioflocculant from Bacillus licheniformis. Applied and Environmental Microbiology. 2010, 76(9): 2778–2782.

获得的教学和科研表彰

欧洲动脉粥样硬化协会青年人员研究奖（Young Investigator Fellowship of 2015 European Atherosclerosis Society (EAS)）

弗里堡大学最佳优秀博士论文奖 弗里堡大学（瑞士）University of Fribourg，2014

熊裕焱  

所属部门： 医学院

职称： 教授

研究方向：

（1）衰老和肥胖引起的心血管疾病和2型糖尿病发病机制的研究

（2）动脉粥样硬化临床诊断分子标志物的研究

（3）不同应激条件下mTOR信号通路调控分子机制的研究

（4）探究细胞凋亡和细胞自噬调节心血管疾病和肿瘤发病机制的研究

联系方式：E-mail: yuyan.xiong@nwu.edu.cn